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CLINICAL
OUTCOMES
The
Closure Procedure: A Treatment That Works
Clinical
results indicate that the Closure procedure can be effective
at closing the vein and significantly reducing patient
symptoms.
At
two years following treatment, patients who had undergone
the Closure procedure reported superior quality of life
compared to vein stripping patients.1
The
Closure procedure has proven to be highly effective,
with more than 90% of veins treated remaining reflux
free at two years.1
Results also demonstrate long-term relief of symptoms.2
Patient
Symptoms Reported at Follow-up2
Three
randomized trials of the Closure procedure versus vein
stripping, including the multi-center comparative trial
published August 2003 in the Journal of Vascular Surgery,
show very similar results.2,3,4
In the most recent trial every statistically significant
outcome was in favor of the Closure procedure, resulting
in2 :
- Experienced
less post-operative pain and bruising
- Resumed
normal activities within one day
- Returned
to work more than a week earlier than vein stripping
patients
Visual
Results5:
| Pre-treatment |
One
week post-treatment |
Percent
of Legs Without Varicose Veins at Follow-up
The Closure procedure is shown to be effective as vein
stripping in delaying the reappearance of varicose veins.
| Treatment |
1
Year |
2
Years |
|
Closure6
Vein Stripping7
Ligation7
|
90%
85%
86% |
87%
75%
57% |
1
Lurie F, Creton D, Eklof B, Kabnick LS, Kistner
RL, Pichot O, et al. Prospective randomized study of
endovenous radiofrequency obliteration (Closure) versus
ligation and stripping in a selected patient population
(EVOLVES study). J Vasc Surg 2003;38:207-14.
2 Date
on file - VNUS Medical Technologies, Inc.
3 Stötter
L. Schaaf I, Fendl R, Bockelbrink A. Randomized Study
to Compare the Closure Procedure, Invagination Stripping
and Cryo Stripping for Treatment of the Greater Saphenous
Vein. Abstract submitted to German Society for Phlebology
for presentation Sept. 2003.
4 Rautio
T, Ohinmaa A, Perälä J, Ohtonen P, Heikkinen
T, Wiik H, et al. Endovenous obliteration versus conventional
stripping operation in the treatment of primary varicose
veins: A randomized controlled trial with comparison
of costs. J Vasc Surg 2002;35:958-65.
5 Photos
Courtesy of Michael A. Vasquez, MD, F.A.C.S.
6 Merchant
RF, DePalma RG, Kabnick LS. Endovascular Obliteration
of Saphenous Reflux: A Multicenter Study. J Vasc Surg
2002;35:1190-6.
7 Jones
L et al. Neovascularisation is the Principal Cause of
Varicose Vein Recurrence: Results of a Randomized Trial
Of Stripping The Long Saphenous Vein. Eur J Vasc Endovasc
Surg 1996;12:442-445
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